Respiratory Syncytial Virus Infection and Bronchiolitis

被引:202
作者
Piedimonte, Giovanni [1 ,2 ]
Perez, Miriam K. [1 ,3 ]
机构
[1] Cleveland Clin, Pediat Inst, Cleveland, OH 44106 USA
[2] Cleveland Clin, Childrens Hosp Rehabil, Cleveland, OH 44106 USA
[3] Independence Family Hlth Ctr, Dept Community Pediat, Independence, OH USA
关键词
D O I
10.1542/pir.35-12-519
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Practice Gaps 1. Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children worldwide. Although the most effective management of this infection remains supportive care, many patients continue to be managed with therapies that lack the support of scientific evidence. 2. Although the quest for a safe and effective vaccine remains unsuccessful, themore vulnerable patients can be protected with passive prophylaxis. Because of limited clinical benefits and high costs, RSV prophylaxis should be limited to high-risk infants as directed by the most current evidence-based guidelines that, however, are not consistently followed. 3. The acute phase of this infection is often followed by episodes of wheezing that recur for months or years and usually lead to a physician diagnosis of asthma. The phenotype of post-RSV wheezing is different from atopic asthma, yet it is usually managed using the same pharmacologic therapy with often ineffective results. Objectives After reading this article, readers should be able to: 1. Understand the microbiology, epidemiology, pathophysiology, and clinical manifestations of RSV bronchiolitis in infants and children. 2. Know the scientific evidence relevant to prophylactic and therapeutic strategies currently available and recognize the lack of evidence concerning several pharmacologic agents commonly used in the management of bronchiolitis. 3. Be aware of alternative pharmacologic strategies currently being evaluated. 4. Learn the epidemiologic and experimental information suggesting the existence of a link between early-life infection with RSV and the subsequent development of recurrent wheezing and asthma in childhood and adolescence.
引用
收藏
页码:519 / 530
页数:12
相关论文
共 10 条
  • [1] Respiratory Syncytial Virus and Recurrent Wheeze in Healthy Preterm Infants
    Blanken, Maarten O.
    Rovers, Maroeska M.
    Molenaar, Jorine M.
    Winkler-Seinstra, Pauline L.
    Meijer, Adam
    Kimpen, Jan L. L.
    Bont, Louis
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (19) : 1791 - 1799
  • [2] Bronchodilators for bronchiolitis
    Gadomski, Anne M.
    Brower, Melissa
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2010, (12):
  • [3] MODES OF TRANSMISSION OF RESPIRATORY SYNCYTIAL VIRUS
    HALL, CB
    DOUGLAS, RG
    [J]. JOURNAL OF PEDIATRICS, 1981, 99 (01) : 100 - 103
  • [4] Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
    Nair, Harish
    Nokes, D. James
    Gessner, Bradford D.
    Dherani, Mukesh
    Madhi, Shabir A.
    Singleton, Rosalyn J.
    O'Brien, Katherine L.
    Roca, Anna
    Wright, Peter F.
    Bruce, Nigel
    Chandran, Aruna
    Theodoratou, Evropi
    Sutanto, Agustinus
    Sedyaningsih, Endang R.
    Ngama, Mwanajuma
    Munywoki, Patrick K.
    Kartasasmita, Cissy
    Simoes, Eric A. F.
    Rudan, Igor
    Weber, Martin W.
    Campbell, Harry
    [J]. LANCET, 2010, 375 (9725) : 1545 - 1555
  • [5] Null D, 1998, PEDIATRICS, V102, P531, DOI 10.1542/peds.102.3.531
  • [6] Patel H, 2004, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD004878
  • [7] Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis
    Ralston, Shawn L.
    Lieberthal, Allan S.
    Meissner, H. Cody
    Alverson, Brian K.
    Baley, Jill E.
    Gadomski, Anne M.
    Johnson, David W.
    Light, Michael J.
    Maraqa, Nizar F.
    Mendonca, Eneida A.
    Phelan, Kieran J.
    Zorc, Joseph J.
    Stanko-Lopp, Danette
    Brown, Mark A.
    Nathanson, Ian
    Rosenblum, Elizabeth
    Sayles, Stephen, III
    Hernandez-Cancio, Sinsi
    [J]. PEDIATRICS, 2014, 134 (05) : E1474 - E1502
  • [8] Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13
    Sigurs, N
    Gustafsson, PM
    Bjarnason, R
    Lundberg, F
    Schmidt, S
    Sigurbergsson, F
    Kjellman, B
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (02) : 137 - 141
  • [9] Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
    Stein, R
    Sherrill, D
    Morgan, WJ
    Holberg, CJ
    Halonen, M
    Taussig, LM
    Wright, AL
    Martinez, FD
    [J]. LANCET, 1999, 354 (9178) : 541 - 545
  • [10] RETRACTED: Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children (Retracted Article)
    Ventre, K.
    Randolph, A. G.
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2007, (01):