PRELIMINARY NEUROCHEMICAL FINDINGS IN NON-ALZHEIMER DEMENTIA DUE TO LOBAR ATROPHY

被引：63
作者：
FRANCIS, PT [1 ]
HOLMES, C [1 ]
WEBSTER, MT [1 ]
STRATMANN, GC [1 ]
PROCTER, AW [1 ]
BOWEN, DM [1 ]
机构：
[1] INST NEUROL,MIRIAM MARKS DEPT NEUROCHEM,1 WAREFIELD ST,LONDON WC1N 1PJ,ENGLAND
来源：
DEMENTIA | 1993年 / 4卷 / 3-4期
关键词：
PICKS DISEASE; DEMENTIA OF FRONTAL LOBE TYPE; METABOLISM; DIETARY CHANGES; SEROTONIN; SOMATOSTATIN;
D O I：
10.1159/000107319
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Non-Alzheimer's dementia due to lobar atrophy had choline acetyltransferase activities comparable with control rather than Alzheimer's disease values, based on 3 autopsy proven cases on Pick's disease and biopsies from 3 examples of dementia of frontal lobe type. Muscarinic cholinergic receptors were relatively spared only in Alzheimer's disease. Serotonin receptors were markedly reduced (based on Pick cases) whereas measures that reflected presynaptic serotonergic activity were either not affected or increased. Cerebrospinal fluid and brain tissue measurements suggested that inhibitory interneurones and dopamine release were relatively spared. There was no in vitro evidence of hypometabolism.
引用
收藏
页码：172 / 177
页数：6
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