A case report on the efficacy of vigabatrin analogue (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115) in a patient with infantile spasms

被引：22

作者：

Doumlele, Kyra ^{[1
]}

Conway, Erin ^{[1
]}

Hedlund, Julie ^{[1
]}

Tolete, Patricia ^{[1
]}

Devinsky, Orrin ^{[1
]}

机构：

[1] NYU, Sch Med, Comprehens Epilepsy Ctr, 223 East 34th St, New York, NY 10016 USA

来源：

EPILEPSY & BEHAVIOR CASE REPORTS | 2016年 / 6卷

关键词：

West Syndrome; Infantile spasms; Epileptic spasms; Epilepsy; CPP-115;

D O I：

10.1016/j.ebcr.2016.08.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

West Syndromeis characterized by infantile spasms, a hypsarrhythmic electroencephalogram(EEG) pattern, and a poor neurodevelopmental prognosis. First-line treatments include adrenocorticotrophic hormone (ACTH) and vigabatrin, but adverse effects often limit their use. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity. Here, we present a child treatedwith CPP-115 through an investigational new drug protocol who experienced a marked reduction of seizures with no evidence of retinal dysfunction. Given the potential consequences of ongoing infantile spasms and the limitations of available treatments, further assessment of CPP-115 is warranted. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：67 / 69

页数：3

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