METABOLISM OF 2-CHLORO-N-ISOPROPYLACETANILIDE (PROPACHLOR) IN THE RAT

被引：31

作者：

BAKKE, JE

PRICE, CE

机构：

[1] Metabolism and Radiation Research Laboratory, Science and Education Administration, Federal Research, United States Department of Agriculture, Fargo, North Dakota

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1979年 / 14卷 / 04期

关键词：

gluocuronide; mercapturic acid; metabolism; propachlor;

D O I：

10.1080/03601237909372140

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Eleven urinary metabolites from [14C]propachlor were either identified or characterized by mass spectrometry. Those identified were 2-[Si-(N-acetyl)cysteinyl]-N-isopropylacetanilide, 2-(methylsulfonyl)-acetanilide, 4’-hydroxy-2-(methylsulfonyl)-acetanilide, and 4’-hydroxyacetanilide. Those characterized were N-(1-hydroxyisopropyl)-2-(methylsulfonyl) acetanilide and its glucuronide, the glucuronides of 4l-hydroxy-N-isopropyl-2-(methylsulfonyl)acetanilide, N-(l-hydroxyisopropyl) aniline, 4’-hydroxy-2-(methylsulfonyl)acetanilide, and either N-(1-hydroxy-isopropyl) acetanilide or 2-hydroxy-N-isopropylacetanilide. Copyright © 1979, Taylor & Francis Group, LLC

引用

页码：427 / 441

页数：15

共 8 条

[1] REPLACEMENT OF A CHLORINE WITH A METHYLSULFONYL GROUP IN METABOLISM OF PROPACHLOR (2-CHLORO-N-ISOPROPYLACETANILIDE) [J].

BAKKE, JE ;

FEIL, VJ ;

PRICE, CE .

BIOMEDICAL MASS SPECTROMETRY, 1976, 3 (05) :226-229

[2] MASS-SPECTRAL CHARACTERIZATION OF GLUCURONIDE CONJUGATES OF CRUFOMATE (4-TERT-BUTYL-2-CHLOROPHENYL METHYL METHYLPHOSPHORAMIDATE) METABOLITES [J].

BAKKE, JE ;

PRICE, CE ;

ZAYLSKIE, RG .

BIOMEDICAL MASS SPECTROMETRY, 1976, 3 (06) :329-334

[3]

BAKKE JE, J ENV SCI HLTH

[4] MASS-SPECTRAL ANALYSIS OF GLUCURONIDES [J].

BILLETS, S ;

LIETMAN, PS ;

FENSELAU, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (01) :30-33

[5] MERCAPTURIC ACID FORMATION IN METABOLISM OF PROPACHLOR, CDAA, AND FLUORODIFEN IN RAT [J].

LAMOUREUX, GL ;

DAVISON, KL .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1975, 5 (06) :497-506

[6] SULFATE ESTER CONJUGATES . A ONE-STEP METHOD FOR REPLACING SULFATE WITH AN ACETYL GROUP [J].

PAULSON, GD ;

PORTNOY, CE .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1970, 18 (01) :180-&

[7]

PAULSON GD, 1971, J AGR FOOD CHEM, V19, P417

[8]

18 PACK TECHN B

← 1 →