Rapid Onset of Inflammatory Bowel Disease alter Receiving Secukinumab Infusion

被引：58

作者：

Wang, Jingzhou ^{[1
]}

Bhatia, Arvin ^{[2
]}

Cleveland, Noa Krugliak ^{[3
]}

Gupta, Nina ^{[3
]}

Dalal, Sushila ^{[3
]}

Rubin, David T. ^{[3
]}

Sakuraba, Atsushi ^{[3
]}

机构：

[1] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA

[2] Northwestern Med Reg Med Grp, Geneva, IL USA

[3] Univ Chicago Med, Inflammatory Bowel Dis Ctr, Chicago, IL 60637 USA

来源：

ACG CASE REPORTS JOURNAL | 2018年 / 5卷

关键词：

D O I：

10.14309/crj.2018.56

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Secukinumab, an interleukin (IL)-17A antagonist, was associated with disease exacerbations in Crohn's disease, and de novo cases of inflammatory bowel disease (IBD) have been reported in studies of rheumatoid diseases. However, there has been no detailed report demonstrating the linkage between secukinumab therapy and new-onset IBD. We present a unique case of rapid-onset fulminant colitis after receiving 1 dose of secukinumab infusion followed by improvement with combination antibiotics, corticosteroids, and calcineurin inhibition. Health care providers should be aware of the possible association between IL-17 antagonist therapy and the risk of developing new-onset fulminant IBD.

引用

页数：3

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