INFLUENCE OF MISONIDAZOLE ON THE RADIOSENSITIVITY OF A HUMAN-MELANOMA IN NUDE-MICE - TIME-DEPENDENT INCREASE IN SURVIVING FRACTION

被引：27

作者：

GUICHARD, M ^{[1
]}

LANGENOMRI, FD ^{[1
]}

MALAISE, EP ^{[1
]}

机构：

[1] INST GUSTAVE ROUSSY,16 BIS AVE PAUL VAILLANT COUTURIER,F-94800 VILLEJUIF,FRANCE

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 04期

关键词：

Clonogenic assay; Melanoma; Misonidazole; Repair of PLD; Xenografts of human tumors;

D O I：

10.1016/0360-3016(79)90811-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using an in vitro colony method, we tested the effect of 1 mg/g misonidazole on a human melanoma transplanted into nude mice. The enhancement ratios were 1.6 when the cells were plated immediately after irradiation and 2.0 when plating was done after a delay of 6 hr. Whereas repair of potentially lethal damage (PLD) was demonstrated in cells without misonidazole, with the drug the surviving fraction was the same immediately or 6 hr after irradiation. Our interpretation of this finding is discussed. © 1979.

引用

页码：487 / 489

页数：3

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