A conductor layout technique is described that reduces nearest-neighbor crosstalk for multiconductor signal buses with applications in high-speed digital and microwave pulse integrated circuits, Periodic transposition of conductors in a bus increases the average spacing of formerly nearest neighbors and thus decreases their capacitive and inductive coupling compared with ordinary parallel conductors, A conductor transposition pattern is evaluated for crosstalk, propagation delay, and chip area, SPICE simulations demonstrate that conductor transposition reduces, in certain situations, near- and far-end nearest-neighbor crosstalk by roughly 40% compared with parallel conductors, Quantitative guidelines are developed for reducing nearest-neighbor crosstalk in a transposed five-conductor bus, including effects of signal rise time, source resistance, load capacitance, and bus length.