GLUTAMATERGIC REGULATION OF CANNABINOID RECEPTOR GENE-EXPRESSION IN THE CAUDATE-PUTAMEN

被引：27
作者：
MAILLEUX, P
VANDERHAEGHEN, JJ
机构：
[1] Unité de Recherche sur le Cerveau, Faculté de Médecine, Université Libre de Bruxelles, B-1070 Brussel, Campus Erasme, CP 601
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 266卷 / 02期
关键词：
CANNABIS; DELTA-9-TETRAHYDROCANNABINOL (THC); CEREBRAL DECORTICATION; MK-801; NMDA RECEPTOR; IN SITU HYBRIDIZATION;
D O I：
10.1016/0922-4106(94)90110-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glutamatergic regulation of delta-9-tetrahydrocannabinol (THC) receptor gene expression in the adult rat dorsal striatum following a 2 week unilateral cerebral decortication or pharmacological treatment with MK-801 was investigated by quantitative in situ hybridization. The caudate-putamen on the side of the cerebral decortication contains about 30% significantly lower mRNA levels than the control. In addition, we observed a 52% significant decrease in THC receptor mRNA levels in intact dorsal striatum after treatment with MK-801. Together these results suggest that in vivo, through the NMDA receptor subtype, glutamate up-regulates THC receptor gene expression in the rat caudate-putamen.
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收藏
页码：193 / 196
页数：4
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