NEW BIOACTIVE TAXOIDS FROM CELL-CULTURES OF TAXUS-BACCATA

被引：61

作者：

MA, WW ^{[1
]}

PARK, GL ^{[1
]}

GOMEZ, GA ^{[1
]}

NIEDER, MH ^{[1
]}

ADAMS, TL ^{[1
]}

AYNSLEY, JS ^{[1
]}

SAHAI, OP ^{[1
]}

SMITH, RJ ^{[1
]}

STAHLHUT, RW ^{[1
]}

HYLANDS, PJ ^{[1
]}

BITSCH, F ^{[1
]}

SHACKLETON, C ^{[1
]}

机构：

[1] CHILDRENS HOSP,OAKLAND RES INST,OAKLAND,CA 94609

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 01期

关键词：

D O I：

10.1021/np50103a016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-0-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.

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页码：116 / 122

页数：7

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