ANTIOXIDATIVE ACTIVITY OF SYNTHETIC MELANINS - CARDIOLIPIN LIPOSOME MODEL

被引：49

作者：

POREBSKABUDNY, M ^{[1
]}

SAKINA, NL ^{[1
]}

STEPIEN, KB ^{[1
]}

DONTSOV, AE ^{[1
]}

WILCZOK, T ^{[1
]}

机构：

[1] ACAD SCI USSR,INST CHEM PHYS,MOSCOW V-71,USSR

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1116卷 / 01期

关键词：

CATECHOLAMINE-MELANIN; DOPA-MELANIN; ANTIOXIDANT; CARDIOLIPIN; LIPID PEROXIDATION; MELANIN;

D O I：

10.1016/0304-4165(92)90121-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe2+-ascorbic acid-induced peroxidation of cardiolipin liposomes has been studied. All these melanins are able to inhibit both the ultraviolet- and the Fe2+-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin < melanin synthesized from dopamine in the presence of Cu2+ < DOPA - melanin < melanin synthesized from adrenaline in the presence of Cu2+ congruent-to adrenolutin-melanin, and correlates with their ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.

引用

页码：11 / 16

页数：6

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