A NOVEL ANTICHOLINESTERASE THB013 - BIOCHEMICAL AND BEHAVIORAL-STUDIES

被引：3

作者：

ADEM, A

MOHAMMED, AH

WINBLAD, B

HENRIKSSON, BE

机构：

[1] Department of Geriatric Medicine, Karolinska Institute, Huddinge University Hospital, Huddinge

来源：

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION | 1994年 / 8卷 / 1-2期

关键词：

ALZHEIMERS DISEASE; ACETYLCHOLINE RELEASE; CHOLINESTERASES; CHOLINERGIC; MUSCARINIC; SPATIAL LEARNING; TACRINE; TACRINE ANALOGS; THB; 013;

D O I：

10.1007/BF02250925

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical trials with tacrine (THA) have resulted in elevations of liver enzymes in Alzheimer patients that showed improvement. In an effort to minimize these side effects several THA analogues were synthesized. These analogues were compared to THA in biochemical as well as behavioural studies. In this study, the biochemical effects of THA and one of these analogs, THB 013, on plasma cholinesterase activity, cholinergic receptors as well as the effect of these drugs on spatial learning in adult rats were examined. THB 013 was, at lower concentration, more efficacious in inhibiting plasma cholinesterase as well as blocking the scopolamine induced disruption of spatial learning when administered 10 min before the scopolamine injection. It is possible that THB 013 with more potent cholinergic effects than THA might be useful in the treatment of Alzheimer's disease.

引用

页码：139 / 148

页数：10

共 21 条

[1]

ADEM A, 1990, J NEURAL TRANSM-PARK, V2, P113, DOI 10.1007/BF02252923

[2] SHORT-TERM-MEMORY IN RHESUS-MONKEY - DISRUPTION FROM ANTI-CHOLINERGIC SCOPOLAMINE [J].