EARLY EVOLUTIONARY ORIGIN OF MAJOR HOMEODOMAIN SEQUENCE CLASSES

被引：127
作者：
KAPPEN, C
SCHUGHART, K
RUDDLE, FH
机构：
[1] MAX PLANCK INST IMMUNBIOL, W-7800 FREIBURG, GERMANY
[2] YALE UNIV, DEPT BIOL, NEW HAVEN, CT 06511 USA
[3] YALE UNIV, DEPT HUMAN GENET, NEW HAVEN, CT 06511 USA
来源：
GENOMICS | 1993年 / 18卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1426
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have analyzed the relationships of 337 homeodomain and related sequences using a distance matrix approach. Based on our results, homeodomain sequences can be classified into at least 30 distinguishable classes. Sequences belonging to the same class are highly similar to each other but there are no obvious close relationships between the separate classes. Since many of these classes each contain sequences from quite diverged organisms, we conclude that these separate classes of homeodomain sequences were established early during evolution. © 1993 Academic Press, Inc.
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页码：54 / 70
页数：17
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