A-78773 - A SELECTIVE, POTENT 5-LIPOXYGENASE INHIBITOR

被引：0

作者：

BELL, RL

BROOKS, DW

YOUNG, PR

LANNI, C

STEWART, AO

BOUSKA, J

MALO, PE

CARTER, GW

机构：

来源：

JOURNAL OF LIPID MEDIATORS | 1993年 / 6卷 / 1-3期

关键词：

5-LIPOXYGENASE; LEUKOTRIENE; INHIBITOR;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The potency and selectivity of A-78773, a newly discovered 5-lipoxygenase inhibitor, were examined. The compound was significantly more potent than zileuton in inhibiting leukotriene formation in cell free lysates and in isolated human neutrophils. A-78773 inhibited a RBL cell lysate 5-lipoxygenase at concentrations 2 orders of magnitude lower than those required to inhibit rabbit reticulocyte 15-lipoxygenase or human platelet 12-lipoxygenase. The compound was also a potent, long lasting, orally active inhibitor of leukotriene formation ex vivo in dogs and in vivo in the rat. In experiments where leukotriene formation was completely inhibited, no increase in eicosanoids from other pathways was observed. A-78773 should prove to be a valuable clinical tool in treating leukotriene mediated diseases.

引用

页码：259 / 264

页数：6

共 10 条

[1]

CARTER GW, 1991, J PHARMACOL EXP THER, V256, P929

[2]

COLLAWN C, 1992, AM J GASTROENTEROL, V87, P342

[3]

ISRAEL E, 1992, American Review of Respiratory Disease, V145, pA16

[4] THE EFFECTS OF A 5-LIPOXYGENASE INHIBITOR ON ASTHMA INDUCED BY COLD, DRY AIR [J].