Recent infertility literature has focused on the epidemiologic evaluation of diagnostic and therapeutic measures. The predictive value of the postcoital test and the sperm penetration assays has been called into question, particularly for female factor infertility. Several studies have sought better prognostic guidelines for assisted reproductive technologies such as artificial insemination by donor and in vitro fertilization and embryo transfer, as well as more cost-effective screening measures for evaluating infertile couples. Recent epidemiologic investigations have found no adverse effects of infertility therapy on the health of mothers or their babies.