STAT3 - A STAT FAMILY MEMBER ACTIVATED BY TYROSINE PHOSPHORYLATION IN RESPONSE TO EPIDERMAL GROWTH-FACTOR AND INTERLEUKIN-6

被引：1864

作者：

ZHONG, Z

WEN, ZL

DARNELL, JE

机构：

[1] Laboratory of Molecular Cell Biology, Rockefeller University, New York

来源：

SCIENCE | 1994年 / 264卷 / 5155期

关键词：

D O I：

10.1126/science.8140422

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1alpha), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.

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页码：95 / 98

页数：4

相关论文

共 23 条

[1]

AKIYAMA T, 1987, J BIOL CHEM, V262, P5592

[2]

Ausubel F. M., 1993, CURRENT PROTOCOLS MO

[3] CHARACTERIZATION OF A PATHWAY FOR CILIARY NEUROTROPHIC FACTOR SIGNALING TO THE NUCLEUS [J].

BONNI, A ;

FRANK, DA ;

SCHINDLER, C ;

GREENBERG, ME .

SCIENCE, 1993, 262 (5139) :1575-1579

[4] THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION [J].

FU, XY ;

SCHINDLER, C ;

IMPROTA, T ;

AEBERSOLD, R ;

DARNELL, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7840-7843

[5] ISGF3, THE TRANSCRIPTIONAL ACTIVATOR INDUCED BY INTERFERON-ALPHA, CONSISTS OF MULTIPLE INTERACTING POLYPEPTIDE-CHAINS [J].

FU, XY ;

KESSLER, DS ;

VEALS, SA ;

LEVY, DE ;

DARNELL, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) :8555-8559

[6] TRANSCRIPTION FACTOR P91 INTERACTS WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND MEDIATES ACTIVATION OF THE C-FOS GENE PROMOTER [J].

FU, XY ;

ZHANG, JJ .

CELL, 1993, 74 (06) :1135-1145

[7] REQUIREMENT OF TYROSINE PHOSPHORYLATION FOR RAPID ACTIVATION OF A DNA-BINDING FACTOR BY IL-4 [J].

KOTANIDES, H ;

REICH, NC .

SCIENCE, 1993, 262 (5137) :1265-1267

[8] TYROSINE PHOSPHORYLATION OF DNA-BINDING PROTEINS BY MULTIPLE CYTOKINES [J].

LARNER, AC ;

DAVID, M ;

FELDMAN, GM ;

IGARASHI, K ;

HACKETT, RH ;

WEBB, DSA ;

SWEITZER, SM ;

PETRICOIN, EF ;

FINBLOOM, DS .

SCIENCE, 1993, 261 (5129) :1730-1733

[9] OVERLAPPING ELEMENTS IN THE GUANYLATE-BINDING PROTEIN GENE PROMOTER MEDIATE TRANSCRIPTIONAL INDUCTION BY ALPHA AND GAMMA INTERFERONS [J].

LEW, DJ ;

DECKER, T ;

STREHLOW, I ;

DARNELL, JE .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :182-191

[10] ASSOCIATION OF TRANSCRIPTION FACTOR APRF AND PROTEIN-KINASE JAK1 WITH THE INTERLEUKIN-6 SIGNAL TRANSDUCER GP130 [J].

LUTTICKEN, C ;

WEGENKA, UM ;

YUAN, JP ;

BUSCHMANN, J ;

SCHINDLER, C ;

ZIEMIECKI, A ;

HARPUR, AG ;

WILKS, AF ;

YASUKAWA, K ;

TAGA, T ;

KISHIMOTO, T ;

BARBIERI, G ;

PELLEGRINI, S ;

SENDTNER, M ;

HEINRICH, PC ;

HORN, F .

SCIENCE, 1994, 263 (5143) :89-92