ADAPTIVE ASSIGNMENT VERSUS BALANCED RANDOMIZATION IN CLINICAL-TRIALS - A DECISION-ANALYSIS

被引：121

作者：

BERRY, DA ^{[1
]}

EICK, SG ^{[1
]}

机构：

[1] AT&T BELL LABS,NAPERVILLE,IL 60566

来源：

STATISTICS IN MEDICINE | 1995年 / 14卷 / 03期

关键词：

D O I：

10.1002/sim.4780140302

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We compare balanced randomization with four adaptive treatment allocation procedures in a clinical trial involving two treatments. The objective is to treat as many patients in and out of the trial as effectively as possible. Randomization is a satisfactory solution to the decision problem when the disease in question is at Least moderately common. Adaptive procedures are more difficult to use, but might play a role in clinical research when a substantial proportion of all patients with the disease are included in the trial.

引用

页码：231 / 246

页数：16

共 22 条

[1] SEQUENTIAL MEDICAL TRIALS [J].