PCBS AS ENVIRONMENTAL ESTROGENS - TURTLE SEX DETERMINATION AS A BIOMARKER OF ENVIRONMENTAL CONTAMINATION

被引：288

作者：

BERGERON, JM ^{[1
]}

CREWS, D ^{[1
]}

MCLACHLAN, JA ^{[1
]}

机构：

[1] NIEHS,RES TRIANGLE PK,NC 27709

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1994年 / 102卷 / 09期

关键词：

D O I：

10.2307/3432139

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polychlorinated biphenyls (PCBs) are wide-spread, low-level environmental pollutants associated with adverse heath effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, including humans, particularly during development. Research on the mechanism through which these compounds act to alter reproductive function indicates estrogenic activity, whereby the compounds may be altering sexual differentiation. Here we demonstrate the estrogenic effect of some PCBs by reversing gonadal sex in a reptile species that exhibits temperature-dependent sex determination.

引用

页码：780 / 781

页数：2

共 17 条

[1]

BERN HA, 1992, CHEM INDUCED ALTERAT, P9

[2] SEX REVERSAL BY ESTRADIOL IN 3 REPTILIAN ORDERS [J].