AN INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION/ELECTROPHILIC CYCLIZATION SEQUENCE TO GIVE CYCLIC ETHERS

被引：23

作者：

BEEBE, X ^{[1
]}

CHIAPPARI, CL ^{[1
]}

KURTH, MJ ^{[1
]}

SCHORE, NE ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 26期

关键词：

D O I：

10.1021/jo00078a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular 1,3-dipolar cycloaddition/electrophilic cyclization sequence has been developed for the synthesis of cyclic ethers. This approach utilizes a diastereoselective nitrile oxide 1,3-dipolar cycloaddition to give furoisoxazoles, which undergo subsequent electrophilic cyclization to afford substituted tetrahydrofurans.

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页码：7320 / 7321

页数：2

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