Association between anti-citrullinated alpha enolase antibodies and clinical features in a cohort of patients with rheumatoid arthritis: a pilot study

被引:5
作者
Alunno, A. [1 ]
Bistoni, O. [1 ]
Pratesi, F. [2 ]
Topini, F. [1 ]
Puxeddu, I [2 ]
Valentini, V. [1 ]
Cafaro, G. [1 ]
Bartoloni, E. [1 ]
Migliorini, P. [2 ]
Gerli, R. [1 ]
机构
[1] Univ Perugia, Dept Med, Rheumatol Unit, Edificio C,5 Piano,Piazzale Menghini 1, I-96129 S Andrea Delle Fratte, PG, Italy
[2] Univ Pisa, Dept Clin & Expt Med, Clin Immunol & Allergy Unit, Pisa, Italy
关键词
Rheumatoid arthritis;
D O I
10.4081/reumatismo.2018.1028
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In recent years several antibodies against citrullinated peptides (ACPAs) have been identified in patients with rheumatoid arthritis (RA) and their pathogenic, diagnostic and prognostic significance is under intense investigation. Among ACPAs, those targeting citrullinated alpha enolase (anti-CEP1) have been identified in RA but data about their ability to predict the development of erosive disease are conflicting. Furthermore, no data are currently available concerning their possible association with extra-articular manifestations (EAMs) in RA. The aim of this study was to investigate the prevalence and significance of anti-CEP1 from a prognostic point of view. In this pilot study we confirmed that anti-CEP1 Abs are associated with higher prevalence of bone erosions, but we also provided the first evidence of an association between anti-CEP1 Abs and RA interstitial lung disease (ILD). These results provide the basis to investigate the association between anti-CEP1 Abs and EAMs in larger cohorts of RA patients to possibly confirm its role as biomarker for RA-ILD.
引用
收藏
页码:67 / 71
页数:5
相关论文
共 27 条
  • [1] Therapeutic implications of autoantibodies in rheumatoid arthritis
    Aletaha, Daniel
    Blueml, Stephan
    [J]. RMD OPEN, 2016, 2 (01):
  • [2] Circulating Interferon-Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis
    Alunno, Alessia
    Caneparo, Valeria
    Bistoni, Onelia
    Caterbi, Sara
    Terenzi, Riccardo
    Gariglio, Marisa
    Bartoloni, Elena
    Manzo, Antonio
    Landolfo, Santo
    Gerli, Roberto
    [J]. ARTHRITIS CARE & RESEARCH, 2016, 68 (04) : 440 - 445
  • [3] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS
    ARNETT, FC
    EDWORTHY, SM
    BLOCH, DA
    MCSHANE, DJ
    FRIES, JF
    COOPER, NS
    HEALEY, LA
    KAPLAN, SR
    LIANG, MH
    LUTHRA, HS
    MEDSGER, TA
    MITCHELL, DM
    NEUSTADT, DH
    PINALS, RS
    SCHALLER, JG
    SHARP, JT
    WILDER, RL
    HUNDER, GG
    [J]. ARTHRITIS AND RHEUMATISM, 1988, 31 (03): : 315 - 324
  • [4] Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage
    Brink, Mikael
    Verheul, Marije K.
    Ronnelid, Johan
    Berglin, Ewa
    Holmdahl, Rikard
    Toes, Rene E. M.
    Klareskog, Lars
    Trouw, Leendert A.
    Rantapaa-Dahlqvist, Solbritt
    [J]. ARTHRITIS RESEARCH & THERAPY, 2015, 17
  • [5] Antibodies to citrullinated α-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritis
    Fisher, Benjamin A.
    Plant, Darren
    Brode, Monica
    van Vollenhoven, Ronald F.
    Mathsson, Linda
    Symmons, Deborah
    Lundberg, Karin
    Ronnelid, Johan
    Venables, Patrick J.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (06) : 1095 - 1098
  • [6] Gavrila B I, 2016, J Med Life, V9, P144
  • [7] Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis
    Gueler-Yueksel, M.
    Allaart, C. F.
    Goekoop-Ruiterman, Y. P. M.
    de Vries-Bouwstra, J. K.
    van Groenendael, J. H. L. M.
    Mallee, C.
    de Bois, M. H. W.
    Breedveld, F. C.
    Dijkmans, B. A. C.
    Lems, W. F.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (03) : 330 - 336
  • [8] Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    Harre, Ulrike
    Georgess, Dan
    Bang, Holger
    Bozec, Aline
    Axmann, Roland
    Ossipova, Elena
    Jakobsson, Per-Johan
    Baum, Wolfgang
    Nimmerjahn, Falk
    Szarka, Eszter
    Sarmay, Gabriella
    Krumbholz, Grit
    Neumann, Elena
    Toes, Rene
    Scherer, Hans-Ulrich
    Catrina, Anca Irinel
    Klareskog, Lars
    Jurdic, Pierre
    Schett, Georg
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (05) : 1791 - 1802
  • [9] How well do ACPA discriminate and predict RA in the general population: a study based on 12 590 population-representative Swedish twins
    Hensvold, Aase Haj
    Frisell, Thomas
    Magnusson, Patrik K. E.
    Holmdahl, Rikard
    Askling, Johan
    Catrina, Anca Irinel
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (01) : 119 - 125
  • [10] The Role of Citrullinated Protein Antibodies in Predicting Erosive Disease in Rheumatoid Arthritis: A Systematic Literature Review and Meta-Analysis
    Jilani, A. A.
    Mackworth-Young, C. G.
    [J]. INTERNATIONAL JOURNAL OF RHEUMATOLOGY, 2015, 2015