POTENTIAL ROLES FOR 2 HUMAN HOMEODOMAIN CONTAINING PROTEINS IN THE PROLIFERATION AND DIFFERENTIATION OF HUMAN HEMATOPOIETIC PROGENITORS

被引:16
|
作者
KEHRL, JH
DEGUCHI, Y
机构
[1] Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
[2] Department of Immunology, Toyama Medical Pharm. University, Toyama
关键词
HEMATOPOIESIS; HOMEODOMAIN; TRANSCRIPTION FACTORS; DIFFERENTIATION; LINEAGE DETERMINATION;
D O I
10.3109/10428199309145879
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two human homeobox genes, HB9 and HLX, are expressed in hematopoietic progenitors and activated lymphocytes. They are implicated in the proliferation of hematopoietic progenitors in response to growth factors and the differentiation of hematopoietic progenitors to mature cell lineages. RNAs from bone marrow cells of patients with acute myeloid or lymphocytic leukemia have high levels of these two genes while similar RNAs from patients with chronic lymphocytic or myeloid leukemias have nearly normal levels. While the significance of these two genes in leukemogenesis is unknown, they are likely to regulate gene transcription during hematopoiesis and their dysregulation may have dire consequences for hematopoietic cells.
引用
收藏
页码:173 / 176
页数:4
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