ANTIALLERGIC AND ANTIINFLAMMATORY ACTIONS OF 2'-(TETRAZOLE-5-YL)-4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXANILIDE 1,1-DIOXIDE

被引：18

作者：

IKEDA, T ^{[1
]}

KAKEGAWA, H ^{[1
]}

MIYATAKA, H ^{[1
]}

MATSUMOTO, H ^{[1
]}

SATOH, T ^{[1
]}

机构：

[1] TOKUSHIMA BUNRI UNIV, FAC PHARMACEUT SCI, YAMASHIRO CHO, TOKUSHIMA 770, JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)80397-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2'-(Tetrazole-5-yl)-4-hydroxy-2-methyl-2H-1, 2-benzothiazine-3-carbox-anilide 1, 1-dioxide which was designed by the structural hybridization of tranilast and piroxicam, markedly exhibited the inhibitory effects on the antigen-induced histamine release from rat PEC, 48 h homologous PCA in rats and the carrageenin-induced paw edema in mice

引用

页码：709 / 714

页数：6

共 13 条

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