ON THE EFFECT OF PEROXISOMAL BETA-OXIDATION AND CARNITINE PALMITOYLTRANSFERASE ACTIVITY BY EICOSAPENTAENOIC ACID IN LIVER AND HEART FROM RATS

被引：65

作者：

AARSLAND, A

LUNDQUIST, M

BORRETSEN, B

BERGE, RK

机构：

[1] UNIV BERGEN,HAUKELAND SYKEHUS,CLIN BIOCHEM LAB,N-5021 BERGEN,NORWAY

[2] NORSK HYDRO AS,RES CTR,N-3901 PORSGRUNN,NORWAY

来源：

LIPIDS | 1990年 / 25卷 / 09期

关键词：

D O I：

10.1007/BF02537162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Repeated administration of highly purified eicosapentaenoic acid (as ethyl ester) resulted in a decrease in plasma triglycerides and high density lipoprotein (HDL) cholesterol. This was accompanied by a stimulation in the activities of carnitine palmitoyltransferase, fatty acyl-CoA oxidase and peroxisomal β-oxidation in the liver. The results suggest that the triglyceride-lowering effect observed with eicosapentaenoic acid may be due to a reduced supply of fatty acids for hepatic triglyceride synthesis because of increased fatty acid oxidation. Eicosapentaenoic acid feeding marginally affected the triglyceride content of heart and mitochondrial and peroxisomal enzyme activities. © 1990 American Oil Chemists' Society.

引用

页码：546 / 548

页数：3

共 17 条

[1]

AARSLAND A, 1989, J LIPID RES, V30, P1711

[2] ALKYLTHIOACETIC ACID (3-THIA FATTY-ACIDS) - A NEW GROUP OF NON-BETA-OXIDIZABLE, PEROXISOME-INDUCING FATTY-ACID ANALOGS .1. A STUDY ON THE STRUCTURAL REQUIREMENTS FOR PROLIFERATION OF PEROXISOMES AND MITOCHONDRIA IN RAT-LIVER [J].