SELECTIVITY OF THE EXCISION OF ALKYLATION PRODUCTS IN A XERODERMA PIGMENTOSUM-DERIVED LYMPHOBLASTOID LINE

被引：36

作者：

ALTAMIRANODIMAS, M ^{[1
]}

SKLAR, R ^{[1
]}

STRAUSS, B ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT MICROBIOL,CHICAGO,IL 60637

来源：

MUTATION RESEARCH | 1979年 / 60卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0027-5107(79)90184-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lymphoblastoid cells derived from a complementation group C xeroderma patient were unable to remove 06-methyl guanine residues formed in DNA by treatment of cells with low concentrations of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). The xeroderma cells were competent in their ability to excise 3-methyl adenine adducts. MNNG treatment induced excision repair in the xeroderma line and in addition the treatment resulted in the presence of numerous single-strand breaks in the DNA. The single gene, UV-excision-defective mutants of Escherichia coli, uvrA and uvrB, are able to excise MNNG- induced 06-methyl guanine adducts indicating that excision of this compound is not due to operation of the UV endonuclease system. © 1979.

引用

页码：197 / 206

页数：10

共 24 条

[1] XERODERMA PIGMENTOSUM LONG-TERM LYMPHOID LINES WITH INCREASED ULTRAVIOLET SENSITIVITY [J].