EFFECT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON SUBSTANCE P-INDUCED HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS

被引：2

作者：

MCLEOD, J ^{[1
]}

HAYES, NA ^{[1
]}

FOREMAN, JC ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT PHARMACOL,GOWER ST,LONDON WC1E 6BT,ENGLAND

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01969021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

12-O-tetradecanoylphorbol-13-acetate (TPA, 1 to 30 ng/ml) produced a dose-related inhibition of substance P (SP)-induced histamine release from rat peritoneal mast cells. TPA itself induced some histamine release over this concentration range (maximum release about 20% of total). Maximum inhibition of SP-induced release by TPA required preincubation with TPA for at least 10 min. The inhibitory action of TPA was observed in the absence as well as in the presence of extracellular calcium (0.4 m M). Inhibition of diacylglycerol kinase by R 59022 or of diacylglycerol lipase by RHC 80267 reduced SP-induced histamine release. Oleolylacetylglycerol (OAG, 50 μM) inhibited histamine release induced by SP but was less potent than TPA. It is concluded that protein kinase C activation in rat peritoneal mast cells is associated with inhibition of SP-induced histamine release. © 1990 Birkhäuser Verlag.

引用

页码：140 / 142

页数：3

共 10 条

[1] CHARACTERISTICS OF THE EFFECT OF PHORBOL ESTER ON RAT MAST-CELLS - INTERACTION WITH ANTI-IGE [J].

CANTWELL, ME ;

FOREMAN, JC .

AGENTS AND ACTIONS, 1986, 18 (1-2) :77-80

[2]

DECOURCELLES DD, 1985, J BIOL CHEM, V260, P5762

[3]

ENNIS M, 1981, AGENTS ACTIONS, V11, P51

[4] THE EFFECTS OF SUBSTANCE-P ON HISTAMINE AND 5-HYDROXYTRYPTAMINE RELEASE IN THE RAT [J].

FEWTRELL, CMS ;

FOREMAN, JC ;

JORDAN, CC ;

OEHME, P ;

RENNER, H ;

STEWART, JM .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 330 (SEP) :393-411

[5] RELATIONSHIP BETWEEN HISTAMINE SECRETION AND CA-45 UPTAKE BY MAST-CELLS [J].

FOREMAN, JC ;

HALLETT, MB ;

MONGAR, JL .

JOURNAL OF PHYSIOLOGY-LONDON, 1977, 271 (01) :193-214

[6] CALCIUM IONOPHORES AND MOVEMENT OF CALCIUM-IONS FOLLOWING PHYSIOLOGICAL STIMULUS TO A SECRETORY PROCESS [J].

FOREMAN, JC ;

MONGAR, JL ;

GOMPERTS, BD .

NATURE, 1973, 245 (5423) :249-251

[7] ROLE OF ALKALINE-EARTH IONS IN ANAPHYLACTIC HISTAMINE SECRETION [J].

FOREMAN, JC ;

MONGAR, JL .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 224 (03) :753-&

[8] SYNERGISTIC ACTION OF PROTEIN KINASE-C AND CALCIUM FOR HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS [J].

KATAKAMI, Y ;

KAIBUCHI, K ;

SAWAMURA, M ;

TAKAI, Y ;

NISHIZUKA, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 121 (02) :573-578

[9] PROTEIN KINASE-C REGULATION OF THE RECEPTOR-COUPLED CALCIUM SIGNAL IN HISTAMINE-SECRETING RAT BASOPHILIC LEUKEMIA-CELLS [J].

SAGIEISENBERG, R ;

LIEMAN, H ;

PECHT, I .

NATURE, 1985, 313 (5997) :59-61

[10]

SUTHERLAND CA, 1982, J BIOL CHEM, V257, P4006

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