ABNORMAL B-LYMPHOCYTE DEVELOPMENT, ACTIVATION, AND DIFFERENTIATION IN MICE THAT LACK OR OVEREXPRESS THE CD19 SIGNAL-TRANSDUCTION MOLECULE

被引：490

作者：

ENGEL, P ^{[1
]}

ZHOU, LJ ^{[1
]}

ORD, DC ^{[1
]}

SATO, S ^{[1
]}

KOLLER, B ^{[1
]}

TEDDER, TF ^{[1
]}

机构：

[1] UNIV N CAROLINA, DEPT MED, CHAPEL HILL, NC 27510 USA

来源：

IMMUNITY | 1995年 / 3卷 / 01期

关键词：

D O I：

10.1016/1074-7613(95)90157-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD19-deficient mice were generated to examine the role of CD19 in B cell growth regulation in vivo. Deletion of CD19 had no deleterious effects on the generation of B cells in the bone marrow, but there was a significant reduction in the number of B cells in peripheral lymphoid tissues. B cells from CD19-deficient mice exhibited markedly decreased proliferative responses to mitogens, and serum immunoglobulin levels were also significantly decreased. In contrast, mice that overexpressed CD19 had significant defects in early B cell development in the bone marrow, augmented mitogenic responses, and increased serum immunoglobulin levels. These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation.

引用

页码：39 / 50

页数：12

共 57 条

[1] INDUCTION OF SELF-TOLERANCE IN T-CELLS BUT NOT B-CELLS OF TRANSGENIC MICE EXPRESSING LITTLE SELF ANTIGEN [J].