HEREDITARY NEPHROGENIC DIABETES-INSIPIDUS RENALIS IN THE DOG .2. THERAPY

In this study canine hereditary nephrogenic diabetes insipidus in a family of huskies is reported (part 1 diagnosis). In this second part, the following methods of treatment were evaluated: treatment with a low-sodium, low-protein diet in addition to a low-sodium, low-protein diet hydrochlorothiazide (HCT) treatment, also combined with other drugs HCT and indomethacin treatment arginine-vasopressin and vasopressin agonists at high dosages long-term treatment with the vasopressin agonists dDAVP, dVSAVP, and SAVP The daily uptake of drinking water in the treated huskies was easily reduced by a mean value of 30 % without any risks by feeding a low-sodium, low-protein diet. A maximum reduction of the daily water uptake by 24,4 % was achieved with the usual HCT (Esidrix(R)) treatment, indomethacin treatment as well as the combination of both methods. A reduction of the water uptake by 60,2 % was managed by the combination of a low-sodium, low-protein diet, aminophylline, fludrocortisone, and potassium applications with HGT (Esidrix(R)). The use of the AVP agonist dDAVP (Minirin(R)), dVSAVP, and SAVP combined with a low-sodium, low-protein diet allowed a reduction of the daily water uptake by up to 70,38 %, depending on the dosage and the form of application.