SUBMICRON EMULSIONS AS COLLOIDAL DRUG CARRIERS FOR INTRAVENOUS ADMINISTRATION - COMPREHENSIVE PHYSICOCHEMICAL CHARACTERIZATION

被引：254
作者：
BENITA, S
LEVY, MY
机构：
[1] Pharmacy Department, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 11期
关键词：
D O I：
10.1002/jps.2600821102
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Submicron injectable emulsions have been gaining more and more attention in the last few years, mainly as a vehicle for the intravenous administration of lipophilic drugs rather than as an improved delivery system for drug targeting. Submicron emulsions are available, clinically well accepted, and successfully marketed. Novel original emulsion formulations are being extensively investigated and already exhibit improved pharmacological activity; this fact underlines the promising therapeutic properties of these colloidal drug carriers as vehicles for potent lipophilic drugs. It is therefore essential to carry out a comprehensive physicochemical characterization of these submicron emulsions. It is the objective of the present review to emphasize the need for physicochemical studies in the design of new submicron emulsion drug delivery systems and to describe the different approaches available for carrying out such a complete examination of emulsion colloidal drug carrier system.
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页码：1069 / 1079
页数：11
相关论文
共 107 条
[31]  
GROVES MJ, 1984, MODERN METHODS PARTI, P43
[32]  
GROVES MJ, 1985, PARENTERAL TECHNOLOG, P34
[33]  
GUISARD D, 1972, HORM METAB RES, V26, P195
[34]  
HAMILTONATTWELL VL, 1987, J MICROSC-OXFORD, V145, P347
[35]   LASER SELECTED FLUORESCENCE OF HUMAN CATARACTOUS LENSES AT LIQUID-HELIUM TEMPERATURES [J].
HANSON, DM ;
ONDRUSKA, O ;
STRUBINGER, LM ;
LAL, BB .
EXPERIMENTAL EYE RESEARCH, 1983, 37 (02) :145-151
[36]   KINETICS OF CHYLOMICRON TRIGLYCERIDE REMOVAL FROM PLASMA IN RATS - EFFECT OF DOSE ON VOLUME OF DISTRIBUTION [J].
HARRIS, KL ;
HARRIS, PA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 326 (01) :12-16
[37]  
HASHIDA M, 1980, CHEM PHARM BULL, V28, P1009
[38]  
Hunter R.J., 1981, ZETA POTENTIAL COLLO, P59, DOI [DOI 10.1016/B978-0-12-361961-7.50007-9, 10.1016/B978-0-12-361961-7.50007-9]
[39]  
IDSON B, 1988, PHARM DOSAGE FORMS D, V1, P199
[40]  
JEPPSSON R, 1975, ACTA PHARMACOL TOX, V36, P312
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