NITRENDIPINE IS A POTENT INHIBITOR OF THE CA2+-ACTIVATED K+ CHANNEL OF HUMAN ERYTHROCYTES

被引：44

作者：

ELLORY, JC ^{[1
]}

KIRK, K ^{[1
]}

CULLIFORD, SJ ^{[1
]}

NASH, GB ^{[1
]}

STUART, J ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, DEPT HAEMATOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

FEBS LETTERS | 1992年 / 296卷 / 02期

基金：

英国惠康基金;

关键词：

NITRENDIPINE; CA2+-ACTIVATED K+ CHANNEL; ERYTHROCYTE; SICKLE CELL;

D O I：

10.1016/0014-5793(92)80383-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca2+-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipene inhibited K+(Rb-86(+)) influx with an I50, of around 130 nM. Similar results were obtained for K+(Rb-86(+)) efflux, and for K+(Rb-86(+)) influx into cells suspended in a high-K+ medium.

引用

页码：219 / 221

页数：3

共 50 条

[1] The Gardos channel:: a review of the Ca2+-activated K+ channel in human erythrocytes
Maher, AD
Kuchel, PW
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (08): : 1182 - 1197
[2] INDUCTION OF A CA2+-ACTIVATED K+ CHANNEL IN HUMAN ERYTHROCYTES BY MECHANICAL-STRESS
JOHNSON, RM
TANG, K
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1107 (02) : 314 - 318
[3] THE INCREASED K+ LEAK OF MALARIA-INFECTED ERYTHROCYTES IS NOT VIA A CA2+-ACTIVATED K+ CHANNEL
KIRK, K
ELFORD, BC
ELLORY, JC
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1135 (01) : 8 - 12
[4] Mechanism of ATP block of a Ca2+-activated K+ channel on bullfrog erythrocytes.
Shindo, M
Sohma, Y
Imai, Y
BIOPHYSICAL JOURNAL, 1999, 76 (01) : A189 - A189
[5] ATP directly blocks a Ca2+-activated K+ channel on bullfrog erythrocytes.
Shindo, M
Sohma, Y
Imai, Y
BIOPHYSICAL JOURNAL, 1998, 74 (02) : A394 - A394
[6] The Gardos channel:: a review of the Ca2+-activated K+ channel in human erythrocytes (vol 35, pg 1182, 2003)
Maher, AD
Kuchel, PW
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (12): : 1682 - 1682
[7] Endothelins activate Ca2+-activated K+ channel in CD-1 mouse erythrocytes
Rivera, A
Rotter, MA
Brugnara, C
JOURNAL OF GENERAL PHYSIOLOGY, 1998, 112 (01): : 21A - 21A
[8] A novel type of ATP block on a Ca2+-activated K+ channel from bullfrog erythrocytes
Shindo, M
Imai, Y
Sohma, Y
BIOPHYSICAL JOURNAL, 2000, 79 (01) : 287 - 297
[9] CA2+-ACTIVATED K+ CHANNELS IN HUMAN PLATELETS
MAHAUTSMITH, MP
JOURNAL OF PHYSIOLOGY-LONDON, 1994, 476P : P59 - P59
[10] Modulation of Ca2+-activated K+ channels of human erythrocytes by endogenous protein kinase C
Del Carlo, B
Pellegrini, M
Pellegrino, M
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1612 (01): : 107 - 116

← 1 2 3 4 5 →