NITRENDIPINE IS A POTENT INHIBITOR OF THE CA2+-ACTIVATED K+ CHANNEL OF HUMAN ERYTHROCYTES

被引：44

作者：

ELLORY, JC ^{[1
]}

KIRK, K ^{[1
]}

CULLIFORD, SJ ^{[1
]}

NASH, GB ^{[1
]}

STUART, J ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, DEPT HAEMATOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

FEBS LETTERS | 1992年 / 296卷 / 02期

基金：

英国惠康基金;

关键词：

NITRENDIPINE; CA2+-ACTIVATED K+ CHANNEL; ERYTHROCYTE; SICKLE CELL;

D O I：

10.1016/0014-5793(92)80383-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca2+-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipene inhibited K+(Rb-86(+)) influx with an I50, of around 130 nM. Similar results were obtained for K+(Rb-86(+)) efflux, and for K+(Rb-86(+)) influx into cells suspended in a high-K+ medium.

引用

页码：219 / 221

页数：3

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