EPIDERMAL GROWTH-FACTOR AND EPIDERMAL GROWTH-FACTOR RECEPTOR IN PATIENTS WITH GASTRIC-CANCER

被引：0

作者：

ROA, I

ARAYA, JC

DEARETXABALA, X

WISTUBA, I

VILLASECA, M

SAITO, K

NAKAMURA, K

机构：

[1] UNIV LA FRONTERA, HOSP REG TEMUCO, FAC MED, UNIDAD PATOL & SERV, TEMUCO, 30031, CHILE

[2] UNIV LA FRONTERA, HOSP REG TEMUCO, FAC MED, DEPT CIRUG, TEMUCO, CHILE

[3] UNIV LA FRONTERA, DIRECC INEST, UNIDAD ANAT PATOL & CITOPATOL, TEMUCO, CHILE

[4] UNIV TSUKUBA, INST BASIC MED SCI, TSUKUBA, IBARAKI, JAPAN

来源：

REVISTA MEDICA DE CHILE | 1992年 / 120卷 / 01期

关键词：

STOMACH NEOPLASMS; CARCINOMA; EPIDERMAL GROWTH FACTORS; HISTOCYTOCHEMISTRY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 19 patients with advanced gastric cancer the expression of epidermal growth factor receptor and epidermal growth factor (EGF) were studied using immuno histochemical techniques. There were 12 males and the mean age of the group was 54.8 years. Most cases belonged in Borrmann's types III or IV. Tumoral cells were positive for EGF receptor in 9 patients (47%), with a strong reaction in 6. Thirteen of 18 subjects were positive for EGF. The reaction for EGF receptor was positive in 20% of 12 patients with intestinal type tumors and in 67% of 7 patients with difuse tumors. Reaction for EGF was positive in 80% of intestinal type tumors and 64% of difuse tumors. Simultaneous positive reactions for both antigens was observed in 5 of 18 patients, all with difuse type tumors. Signet ring cell tumors showed less positivity than less dffferentiated ones. Thus, the expression of EGF and EGF receptor was higher in our patients with advanced gastric cancer than reported elsewhere.

引用

页码：5 / 12

页数：8