SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES AND THEIR RESISTANCE TO THE ACTION OF SNAKE-VENOM PHOSPHODIESTERASE

被引：0
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作者：
ORETSKAYA, TS
IBRAGIM, HKH
VOLKOV, EM
ROMANOVA, EA
TASHLITSKY, VN
SHABAROVA, ZA
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来源：
BIOORGANICHESKAYA KHIMIYA | 1994年 / 20卷 / 8-9期
关键词：
1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES; MODIFIED OLIGONUCLEOTIDES; SNAKE VENOM PHOSPHODIESTERASE;
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摘要：
Effective methods of multiple incorporations of nucleotides with the inverted configuration of C2' hydroxyl group have been developed. The presence of tU and tC as 3'-terminal oligonucleotide modifications is shown to increase their resistance to snake venom phosphodiesterase. The obtained compounds are promising for the use in antisense biotechnology.
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页码：967 / 974
页数：8
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