SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES AND THEIR RESISTANCE TO THE ACTION OF SNAKE-VENOM PHOSPHODIESTERASE

被引：0

作者：

ORETSKAYA, TS

IBRAGIM, HKH

VOLKOV, EM

ROMANOVA, EA

TASHLITSKY, VN

SHABAROVA, ZA

机构：

来源：

BIOORGANICHESKAYA KHIMIYA | 1994年 / 20卷 / 8-9期

关键词：

1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES; MODIFIED OLIGONUCLEOTIDES; SNAKE VENOM PHOSPHODIESTERASE;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Effective methods of multiple incorporations of nucleotides with the inverted configuration of C2' hydroxyl group have been developed. The presence of tU and tC as 3'-terminal oligonucleotide modifications is shown to increase their resistance to snake venom phosphodiesterase. The obtained compounds are promising for the use in antisense biotechnology.

引用

页码：967 / 974

页数：8

共 6 条

[1] INSITU ACTIVATION OF BIS-DIALKYLAMINOPHOSPHINES - A NEW METHOD FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES ON POLYMER SUPPORTS
BARONE, AD
TANG, JY
CARUTHERS, MH
[J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (10) : 4051 - 4061
[2] JOENS RA, 1984, OLIGONUCLEOTIDE SYNT, P23
[3] FACILE TRANSFORMATION OF BETA-D-RIBOFURANOSYL PURINES AND PYRIMIDINES INTO THEIR RESPECTIVE 3'-DEOXY-THREO-PENTOFURANOSYL NUCLEOSIDES
KAWANA, M
NISHIKAWA, M
YAMASAKI, N
KUZUHARA, H
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (09): : 1593 - 1596
[4] KRYNETSKAYA NF, 1994, BIOORG KHIM+, V20, P669
[5] Maxam A M, 1980, Methods Enzymol, V65, P499
[6] SHMIDT S, 1991, Bioorganicheskaya Khimiya, V17, P823

← 1 →