INTERLEUKIN-1 INDUCES BETA-ENDORPHIN SECRETION VIA FOS AND JUN IN ATT-20 PITUITARY-CELLS

被引：66

作者：

FAGARASAN, MO ^{[1
]}

AIELLO, F ^{[1
]}

MUEGGE, K ^{[1
]}

DURUM, S ^{[1
]}

AXELROD, J ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES FACIL,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21701

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 20期

关键词：

antisense mouse c-fos; antisense mouse c-jun; protein kinase A; protein kinase C;

D O I：

10.1073/pnas.87.20.7871

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous work had shown that interleukin 1 (IL-1), after a long period of treatment, stimulates β-endorphin release and potentiates the effects of secretagogues in AtT-20 cells, a mouse anterior pituitary cell line. Treatment of AtT-20 cells with IL-1 induced a transient and early stimulation of mRNA expression by both immediate-early protooncogenes Fos and Jun (mouse c-fos and c-jun). The effect appeared within 30 min, and returned to basal levels after 2 hr. Desensitization of protein kinase C by phorbol ester pretreatment had no effect on the ability of IL-1 to induce Fos and Jun mRNA expression. Somatostatin, an inhibitor of cAMP and β-endorphin secretion, did not reduce the IL-1 effect on Fos and Jun mRNA expression. Addition to AtT-20 cells of antisense oligonucleotides to Fos and Jun abolished the secretion induced by IL-1. These results indicate that immediate-early signals Fos and Jun are involved in IL-1-induced β-endorphin secretion in AtT-20 cells.

引用

页码：7871 / 7874

页数：4

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