DAILY COCAINE TREATMENT PRODUCES A PERSISTENT REDUCTION OF [H-3] DOPAMINE UPTAKE INVITRO IN RAT NUCLEUS-ACCUMBENS BUT NOT IN STRIATUM

被引：110
|
作者：
IZENWASSER, S
COX, BM
机构：
[1] Department of Pharmacology, Uniformed Services University, Bethesda
来源：
BRAIN RESEARCH | 1990年 / 531卷 / 1-2期
关键词：
Cocaine; Dopamine transport; Dopamine uptake; Nucleus accumbens; Striatum;
D O I：
10.1016/0006-8993(90)90797-F
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Daily administration of cocaine (15 mg/kg i.p. × 3 days) led to a decrease in the total amount of 15 nM [3H]dopamine uptake in rat nucleus accumbens with no changes in uptake in the striatum when tested 24 h after the last injection. There was an increase in the Km for dopamine uptake in the nucleus accumbens of cocaine-treated rats, with no change in the Vmax. Furthermore, cocaine was a more potent inhibitor of [3H]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. © 1990.
引用
收藏
页码：338 / 341
页数：4
相关论文
共 50 条
12345