DAILY COCAINE TREATMENT PRODUCES A PERSISTENT REDUCTION OF [H-3] DOPAMINE UPTAKE INVITRO IN RAT NUCLEUS-ACCUMBENS BUT NOT IN STRIATUM

被引：110
作者：
IZENWASSER, S
COX, BM
机构：
[1] Department of Pharmacology, Uniformed Services University, Bethesda
来源：
BRAIN RESEARCH | 1990年 / 531卷 / 1-2期
关键词：
Cocaine; Dopamine transport; Dopamine uptake; Nucleus accumbens; Striatum;
D O I：
10.1016/0006-8993(90)90797-F
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Daily administration of cocaine (15 mg/kg i.p. × 3 days) led to a decrease in the total amount of 15 nM [3H]dopamine uptake in rat nucleus accumbens with no changes in uptake in the striatum when tested 24 h after the last injection. There was an increase in the Km for dopamine uptake in the nucleus accumbens of cocaine-treated rats, with no change in the Vmax. Furthermore, cocaine was a more potent inhibitor of [3H]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. © 1990.
引用
收藏
页码：338 / 341
页数：4
相关论文
共 18 条
[1]   BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF [H-3] GBR-12935 BINDING INVITRO TO RAT STRIATAL MEMBRANES - LABELING OF THE DOPAMINE UPTAKE COMPLEX [J].
ANDERSEN, PH .
JOURNAL OF NEUROCHEMISTRY, 1987, 48 (06) :1887-1896
[2]   THE DOPAMINE UPTAKE INHIBITOR GBR 12909 - SELECTIVITY AND MOLECULAR MECHANISM OF ACTION [J].
ANDERSEN, PH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (03) :493-504
[3]   HIGH-AFFINITY [H-3] GBR 12783 BINDING TO A SPECIFIC SITE ASSOCIATED WITH THE NEURONAL DOPAMINE UPTAKE COMPLEX IN THE CENTRAL-NERVOUS-SYSTEM [J].
BONNET, JJ ;
PROTAIS, P ;
CHAGRAOUI, A ;
COSTENTIN, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (03) :211-222
[4]  
DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
[5]  
Downs AW, 1932, J PHARMACOL EXP THER, V46, P199
[6]   FOOD REWARD AND COCAINE INCREASE EXTRACELLULAR DOPAMINE IN THE NUCLEUS ACCUMBENS AS MEASURED BY MICRODIALYSIS [J].
HERNANDEZ, L ;
HOEBEL, BG .
LIFE SCIENCES, 1988, 42 (18) :1705-1712
[7]   COMPARISON OF THE EFFECTS OF COCAINE AND OTHER INHIBITORS OF DOPAMINE UPTAKE IN RAT STRIATUM, NUCLEUS-ACCUMBENS, OLFACTORY TUBERCLE, AND MEDIAL PREFRONTAL CORTEX [J].
IZENWASSER, S ;
WERLING, LL ;
COX, BM .
BRAIN RESEARCH, 1990, 520 (1-2) :303-309
[8]  
IZENWASSER S, IN PRESS NEUROPHARMA
[9]   CHARACTERIZATION OF SODIUM-DEPENDENT [H-3] GBR-12935 BINDING IN BRAIN - A RADIOLIGAND FOR SELECTIVE LABELING OF THE DOPAMINE TRANSPORT COMPLEX [J].
JANOWSKY, A ;
BERGER, P ;
VOCCI, F ;
LABARCA, R ;
SKOLNICK, P ;
PAUL, SM .
JOURNAL OF NEUROCHEMISTRY, 1986, 46 (04) :1272-1276
[10]  
JOHANSON CE, 1989, PHARMACOL REV, V41, P3
12