PLASMID CURING ACTION OF IMIPRAMINE IN ESCHERICHIA-COLI-K12

被引：12

作者：

MOLNAR, J ^{[1
]}

BELADI, I ^{[1
]}

HOLLAND, IB ^{[1
]}

机构：

[1] UNIV LEICESTER, SCH BIOL SCI, DEPT GENET, LEICESTER LE1 7RH, W YORKSHIRE, ENGLAND

来源：

GENETICS RESEARCH | 1978年 / 31卷 / 02期

关键词：

D O I：

10.1017/S001667230001795X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Curing of an F-prime plasmid by imipramine was most efficient on bacteria growing semianaerobically at 37 °C. The plasmid curing effect of imipramine was increased in the presence of methylene blue, whilst fluorescein, chlorpromazine-sulphoxide and tetraoxyanthrachinon antagonized the plasmid curing action of the drug. In addition to its plasmid curing effect, imipramine treatment selected for Lon mutants at high frequency. Lon mutants show increased resistance to the drug but cured strains, if Lon+, are not resistant. © 1978, Cambridge University Press. All rights reserved.

引用

页码：197 / 201

页数：5

共 12 条

[1] ALFOLDI L, 1968, J BACTERIOL, V96, P1512
[2] Clowes RC, 1968, EXPT MICROBIAL GENET
[3] FISHMAN V, 1963, P SOC EXP BIOL MED, V112, P501
[4] THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA-COLI
HIROTA, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1960, 46 (01) : 57 - 64
[5] STRUCTURE OF DNA-ACRIDINE COMPLEX
LERMAN, LS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1963, 49 (01) : 94 - &
[6] EFFICIENT CURING OF AN ESCHERICHIA-COLI F-PRIME PLASMID BY PHENOTHIAZINES
MANDI, Y
MOLNAR, J
HOLLAND, IB
BELADI, I
[J]. GENETICAL RESEARCH, 1975, 26 (01) : 109 - 111
[7] ELIMINATION OF TRANSMISSIBLE DRUG-RESISTANCE BYRTREATMENT WITH ACRIFLAVIN
MITSUHASHI, S
KAMEDA, M
HARADA, K
[J]. NATURE, 1961, 189 (476) : 947 - &
[8] ANTIBACTERIAL ACTION AND R-FACTOR-INHIBITING ACTIVITY BY CHLORPROMAZINE
MOLNAR, J
KIRALY, J
MANDI, Y
[J]. EXPERIENTIA, 1975, 31 (04): : 444 - 445
[9] SELECTION OF ION MUTANTS IN ESCHERICHIA-COLI BY TREATMENT WITH PHENOTHIAZINES
MOLNAR, J
HOLLAND, IB
MANDI, Y
[J]. GENETICAL RESEARCH, 1977, 30 (01) : 13 - 20
[10] 2 MODES OF CURING TRANSMISSIBLE BACTERIAL PLASMIDS
SALISBURY, V
DATTA, N
HEDGES, RW
[J]. JOURNAL OF GENERAL MICROBIOLOGY, 1972, 70 (MAY): : 443 - +

← 1 2 →