A DELETION OF MITOCHONDRIAL-DNA IN MURINE DOXORUBICIN-INDUCED CARDIOTOXICITY

被引：92

作者：

ADACHI, K ^{[1
]}

FUJIURA, Y ^{[1
]}

MAYUMI, F ^{[1
]}

NOZUHARA, A ^{[1
]}

SUGIU, Y ^{[1
]}

SAKANASHI, T ^{[1
]}

HIDAKA, T ^{[1
]}

TOSHIMA, H ^{[1
]}

机构：

[1] KURUME UNIV, SCH MED, DEPT BIOCHEM, KURUME, FUKUOKA 830, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A deletion of about 4 kb has been determined in the mutated mitochondrial DNA (mtDNA) in cardiomyocytes with chronic doxorubicin (DOX)-induced cardiotoxicity in mouse. The incidence of the mtDNA deletion increased with the dosage and with the duration of the DOX administration. Coenzyme Q10 administration prevented the mtDNA deletion and decreased the thiobarbituric acid reactive substance content in the heart mitochondria, suggesting some free radical involvement in this mtRNA deletion. This mtDNA deletion may be involved in cardiomyopathy, which is known to be dosage-dependently induced by DOX administration. © 1993 Academic Press, Inc.

引用

页码：945 / 951

页数：7

共 29 条

[21] STUDIES OF SEQUENCE HETEROGENEITY OF MITOCHONDRIAL-DNA FROM RAT AND MOUSE-TISSUES - EVIDENCE FOR AN INCREASED FREQUENCY OF DELETIONS-ADDITIONS WITH AGING [J].

PIKO, L ;

HOUGHAM, AJ ;

BULPITT, KJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 1988, 43 (03) :279-293

[22]

RAJAGOPALAN S, 1988, CANCER RES, V48, P4766

[23] VITAMIN-E-DEFICIENCY HAS A PATHOLOGICAL ROLE IN MYOCYTOLYSIS IN CARDIOMYOPATHIC SYRIAN-HAMSTER (BIO14.6) [J].

SAKANASHI, T ;

SAKO, S ;

NOZUHARA, A ;

ADACHI, K ;

OKAMOTO, T ;

KOGA, Y ;

TOSHIMA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (01) :145-150

[24] MYOCLONIC EPILEPSY AND RAGGED-RED FIBER DISEASE (MERRF) IS ASSOCIATED WITH A MITOCHONDRIAL-DNA TRANSFER RNALYS MUTATION [J].

SHOFFNER, JM ;

LOTT, MT ;

LEZZA, AMS ;

SEIBEL, P ;

BALLINGER, SW ;

WALLACE, DC .

CELL, 1990, 61 (06) :931-937

[25] PROTECTIVE EFFECT OF THE BISPIPERAZINEDIONE ICRF-187 AGAINST DOXORUBICIN-INDUCED CARDIAC TOXICITY IN WOMEN WITH ADVANCED BREAST-CANCER [J].

SPEYER, JL ;

GREEN, MD ;

KRAMER, E ;

REY, M ;

SANGER, J ;

WARD, C ;

DUBIN, N ;

FERRANS, V ;

STECY, P ;

ZELENIUCHJACQUOTTE, A ;

WERNZ, J ;

FEIT, F ;

SLATER, W ;

BLUM, R ;

MUGGIA, F .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (12) :745-752

[26] ADRIAMYCIN STIMULATED SUPEROXIDE FORMATION IN SUB-MITOCHONDRIAL PARTICLES [J].

THAYER, WS .

CHEMICO-BIOLOGICAL INTERACTIONS, 1977, 19 (03) :265-278

[27]

YAMAMOTO Y, 1990, J NUTR SCI VITAMINOL, V36, P505

[28]

YONEDA M, 1990, BIOCHEM INT, V21, P789

[29]

ZEVIANI M, 1988, NEUROLOGY, V38, P1339

← 1 2 3 →