A DELETION OF MITOCHONDRIAL-DNA IN MURINE DOXORUBICIN-INDUCED CARDIOTOXICITY

被引：92

作者：

ADACHI, K ^{[1
]}

FUJIURA, Y ^{[1
]}

MAYUMI, F ^{[1
]}

NOZUHARA, A ^{[1
]}

SUGIU, Y ^{[1
]}

SAKANASHI, T ^{[1
]}

HIDAKA, T ^{[1
]}

TOSHIMA, H ^{[1
]}

机构：

[1] KURUME UNIV, SCH MED, DEPT BIOCHEM, KURUME, FUKUOKA 830, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A deletion of about 4 kb has been determined in the mutated mitochondrial DNA (mtDNA) in cardiomyocytes with chronic doxorubicin (DOX)-induced cardiotoxicity in mouse. The incidence of the mtDNA deletion increased with the dosage and with the duration of the DOX administration. Coenzyme Q10 administration prevented the mtDNA deletion and decreased the thiobarbituric acid reactive substance content in the heart mitochondria, suggesting some free radical involvement in this mtRNA deletion. This mtDNA deletion may be involved in cardiomyopathy, which is known to be dosage-dependently induced by DOX administration. © 1993 Academic Press, Inc.

引用

页码：945 / 951

页数：7

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