PLASMA-RENIN ACTIVITY AS A MARKER FOR GROWTH FAILURE DUE TO SODIUM DEFICIENCY IN YOUNG-RATS

We evaluated the effect of feeding diets of varying sodium content on growth and plasma renin activity (PRA) in young rats. In the first study, four groups of rats were offered 10 g/100 g body weight per day of diets containing either 0.005%, 0.015%, 0.03%, or 0.3% sodium; weight gain per day of each rat was followed for 10-14 days and PRA was then measured. A control group was fed a sodium-replete tryptophan-deficient diet which caused protein calorie malnutrition and inhibited growth. Weight gain (g/day) among the rats on the sodium-deficient diets varied directly (r = 0.81, P <0.001) and PRA inversely (r = -0.82, P <0.001) with dietary sodium content. PRA varied inversely with weight gain (r = -0.84, P <0.001). Insulin-like growth factor-1 (IGF-1), which is depressed in calorie-deficient growth failure, was depressed in all the rats on the low-sodium intakes relative to ad libitum-fed controls, but did not vary in relation to dietary sodium or weight gain within those groups. In rats fed the trytophan-deficient diet, both IGF-1 and weight gain were severely depressed; PRA was normal. In the second study, rats in each of two groups were pair fed, the diet containing either 0.03% or 0.3% sodium matched to rats fed the 0.005% sodium diet; weight gain was followed for 28 days. Both length and weight gain were retarded; PRA again varied inversely with dietary sodium content and with weight gain. We conclude that sodium-deficient diets retard growth in proportion to the degree of dietary sodium deficiency. PRA, but not IGF-1, is a marker for growth retardation due to sodium deficiency.