DIAGNOSIS AND DIFFERENTIATION OF HYPERLIPOPROTEINEMIA

Five patterns of hyperlipoproteinemia are described without giving details for treatment. This system is based on five major lipoprotein patterns which are defined by paper electrophoresis. For more specific diagnosis of hyperlipemia analysis of lipoproteins has been shown to be more useful than chemical determination of plasma lipid concentrations alone. Of great importance is the separation and definition of Type III hyperlipoproteinemia from disorders previously known as familial hypercholesterolemia" or "essensential hyperlipemia". This system for phenotyping hyperlipoproteinemia as introduced by Fredrickson in 1965 is now in use in a large number of laboratories and clinics. It allows the translation of complicated metabolic disorders into simple terms and is the necessary requirement for both further biochemical investigation of lipid transport mechanisms as for proper treatment of lipid transport disorders. © 1969 Springer-Verlag."