ELEVATED SERUM INTERLEUKIN-6 IN POEMS SYNDROME REFLECTS THE ACTIVITY OF THE DISEASE

被引：41

作者：

HITOSHI, S

SUZUKI, K

SAKUTA, M

机构：

[1] Department of Neurology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113

[2] Department of Neurology, Tokyo Metropolitan Geriatric Medical Center, Tokyo and the Department of Hematology and Neurology, Japanese Red Cross Medical Center, Tokyo

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 10期

关键词：

INTERLEUKIN-1-BETA; TUMOR NECROSIS FACTOR-ALPHA; PLASMA CELL DYSCRASIA;

D O I：

10.2169/internalmedicine.33.583

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with POEMS syndrome, which often accompanies plasma cell dyscrasia, the roles of interleukin-6 (IL-6) and other acute phase cytokines are unknown. Serum IL-6, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were measured by the enzyme-linked immunosorbent assay technique in 16 patients with POEMS syndrome and in patients with other neurological diseases (OND) as control. Serum IL-6 was more frequently detected and higher in active POEMS than in stable POEMS or in OND patients. No sample was positive for IL-1beta. TNF-alpha was positive in 3 out of 7 active POEMS patients, but its significance was not definite. Serum IL-6 levels in POEMS patients reflected the disease activity but not the severity of accompanying plasma cell dyscrasia.

引用

页码：583 / 587

页数：5

共 14 条

[1]

Takatsuki K., Sanada I., Plasma cell dyscrasia with polyneuropathy and endocrine disorder: Clinical and laboratory features of 109 reported cases, Jpn J Clin Oncol, 13, (1983)

[2]

Nakanishi T., Sobue I., Toyokura Y., Et al., The Crow-Fukase syndrome: A study of 102 cases in Japan, Neurology, 34, (1984)

[3]

Reulecke M., Dumas M., Meier C., Specific antibody activity against neuroendocrine tissue in a case of POEMS syndrome with IgG gammopathy, Neurology, 38, (1988)

[4]

Nakahara K., Hoketsu Y., Sano Y., Shinmyozu K., Igata A., Improvement of parameters concerning blood coagulation and complement systems in a case of Crow-Fukase syndrome, Rinsho Shinkeigaku, 25, (1985)

[5]

Yoshizaki K., Nakagawa T., Kaieda T., Muraguchi A., Yamamura Y., Kishimoto T., Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors, J Immunol, 128, (1982)

[6]

Muraguchi A., Hirano T., Tang B., Et al., The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells, J Exp Med, 167, (1988)

[7]

Gauldie J., Richards C., Hamish D., Lansdorp P., Baumann H., Interferon B2/ B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, Proc Natl Acad Sci USA, 84, (1987)

[8]

Geiger T., Andus T., Klapproth J., Hirano T., Kishimoto T., Heinrich P.C., Induction of rat acute-phase proteins by interleukin 6 in vivo, Eur J Immunol, 18, (1988)

[9]

Ishibashi T., Kimura H., Shikama Y., Et al., Interleukin-6 is a potent thrombopoietic factor in vivo in mice, Blood, 74, (1989)

[10]

Hitoshi S., Okazawa H., Shimizu J., Suzuki K., Sakuta M., A case of Crow-Fukase syndrome with increased serum interleukin-6, Rinsho Shinkeigaku, 31, (1991)

← 1 2 →