A CASE-CONTROL STUDY OF ALZHEIMERS-DISEASE IN CHINA

被引：109
作者：
LI, G
SHEN, YC
LI, YT
CHEN, CH
ZHAU, YW
SILVERMAN, JM
机构：
[1] BEIJING MED UNIV,INST MENTAL HLTH,BEIJING,PEOPLES R CHINA
[2] CUNY MT SINAI SCH MED,DEPT PSYCHIAT,NEW YORK,NY 10029
来源：
NEUROLOGY | 1992年 / 42卷 / 08期
关键词：
D O I：
10.1212/WNL.42.8.1481
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age- and sex-matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first-degree relatives, family history of psychotic disorders in first-degree relatives, and left-handedness/ambidexterity. A history of arthritis showed a significantly negative association with AD. Neither a family history for Down's syndrome, history of head trauma, nor other conditions that might support immune or viral hypotheses in AD were significantly associated with AD cases. These data support the role of familial/genetic factors in AD.
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页码：1481 / 1488
页数：8
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