GROUP-I PHOSPHOLIPASE-A2 MESSENGER-RNA EXPRESSION IN RAT GLANDULAR STOMACH AND PANCREAS - ONTOGENIC DEVELOPMENT AND EFFECTS OF CORTISONE-ACETATE

被引：8

作者：

DIMBERG, J

GUSTAFSONSVARD, C

WESTROM, B

TAGESSON, C

SODERKVIST, P

机构：

[1] LINKOPING UNIV, FAC HLTH SCI, DEPT CLIN CHEM, S-58185 LINKOPING, SWEDEN

[2] LINKOPING UNIV, FAC HLTH SCI, CLIN RES CTR, S-58185 LINKOPING, SWEDEN

[3] UNIV LUND, DEPT ZOOPHYSIOL, S-22101 LUND, SWEDEN

[4] KAROLINSKA INST, HUDDINGE, SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 01期

关键词：

GROUP-I PHOSPHOLIPASE-A2; ONTOGENY; GLANDULAR STOMACH; (RAT PANCREAS);

D O I：

10.1016/0167-4781(92)90460-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The postnatal development of group I phospholipase A2 (group I PLA2) in the glandular stomach and pancreas of neonatal rats was investigated. The amounts of group I PLA2 mRNA (and also the PLA2 enzymatic activity) in the glandular stomach mucosa increased with age in 3-60-day-old animals. This postnatal development of rat stomach group I PLA2 mRNA agreed with that of group I PLA2 mRNA of the rat pancreas, and thus seems to follow the general development of the gastrointestinal tract during the neonatal period. The latter was further supported by the finding that maturation of group I PLA2 in both the stomach and pancreas was induced precociously in rats treated with cortisone acetate. It is suggested that the stomach group I PLA2 is involved in mucosal eicosanoid production.

引用

页码：47 / 51

页数：5