EFFECTS OF CANNABINOIDS AND COCAINE ON THE MITOGEN-INDUCED TRANSFORMATIONS OF LYMPHOCYTES OF HUMAN AND MOUSE ORIGINS

被引：45

作者：

LUO, YD

PATEL, MK

WIEDERHOLD, MD

OU, DW

机构：

[1] UNIV ILLINOIS,DEPT PATHOL,CHICAGO,IL 60680

[2] WESTSIDE VET ADM MED CTR,CHICAGO,IL 60612

[3] UNIV ILLINOIS,CTR RES RESOURCES,CHICAGO,IL 60680

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 01期

关键词：

D O I：

10.1016/0192-0561(92)90104-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of delta 9-tetrahydrocannabinol (d9THC), delta 6-tetrahydrocannabinol (d6THC), and cocaine on the mitogen-induced transformations of lymphocytes of human and mouse origins were examined in an in vitro system. None of the three compounds is mitogenic in nature. The effects of the two components of marijuana on the mitogen-induced transformation are biphasic. Both compounds stimulated the lymphocyte transformation at low concentrations and inhibited mitogenesis at high concentrations. Cocaine, on the other hand, neither affected mitogen-induced lymphocyte transformations nor altered d9THC's transformation effects when both compounds were added together. Human lymphocytes and mouse splenocytes appeared to respond in similar patterns.

引用

页码：49 / 56

页数：8

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