Application of sialic acid/polysialic acid in the drug delivery systems

被引：44

作者：

Zhang, Ting ^{[1
]}

She, Zhennan ^{[1
]}

Huang, Zhenjun ^{[1
]}

Li, Jing ^{[1
]}

Luo, Xiang ^{[1
]}

Deng, Yihui ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2014年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Sialic acid; Polysialic acid; Drug delivery system; Active targeting; Circulation time;

D O I：

10.1016/j.ajps.2014.03.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The properties of modified biomaterial are gaining more and more importance in drug delivery systems. Sialic acid (SA) and polysialic acid (PSA) serve as endogenous substances, which are non- immunogenic and biodegradable. At the same time, SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain; PSA modification can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood, thus achieving active targeting effect. These properties offer a variety of opportunities for applications in drug delivery systems. This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs, proteins and carriers in drug delivery systems. (C) 2014 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：75 / 81

页数：7

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