1-PHENYL-1H-INDAZOLE DERIVATIVES WITH ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES

被引：0
|
作者：
MOSTI, L
SANSEBASTIANO, L
FOSSA, P
SCHENONE, P
MATTIOLI, F
机构：
[1] UNIV GENOA,IST SCI FARMACEUT,VIALE BENEDETTO XV 3,I-16132 GENOA,ITALY
[2] UNIV GENOA,IST FARMACOL,I-16132 GENOA,ITALY
来源：
FARMACO | 1992年 / 47卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis of 4-hydroxy-1-phenyl-1H-indazole-5-acetic acid 5 4-methoxy-1-phenyl-1H-indazole-5-yl-acetic acid 7 and 5-benzyl-1-phenyl-1H-indazol-4-ol 8, starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one, is described. These compounds showed in mice an analgesic activity superior to that of acetylsalicylic acid and comparable to that of dipyrone; moreover, compound 5 exhibited an appreciable anti-inflammatory activity in rats. Grossbehavioral effects and acute toxicity in mice are also reported.
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页码：357 / 365
页数：9
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