EFFECT OF STAGGERED DOSE OF CALCIUM ON THE BIOAVAILABILITY OF CIPROFLOXACIN

被引：28
|
作者：
LOMAESTRO, BM [1 ]
BAILIE, GR [1 ]
机构：
[1] ALBANY COLL PHARM,ALBANY,NY 12208
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 05期
关键词：
D O I：
10.1128/AAC.35.5.1004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The effect on ciprofloxacin's bioavailability (F) of calcium carbonate given 2 h before ciprofloxacin administration in 12 male volunteers was studied. The relative F with calcium was 0.98, maximum concentration of drug in serum increased significantly from 1.98 to 2.42 mg/liter (P = 0.039), and time to maximum concentration of drug in serum decreased from 1.82 to 1.26 h (P = 0.038). Thus, a single calcium carbonate dose, administered 2 h before ciprofloxacin, does not alter the F of this quinolone.
引用
收藏
页码：1004 / 1007
页数：4
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