PHARMACOLOGIC EFFECTS IN MAN OF A POTENT, LONG-ACTING DOPAMINE RECEPTOR AGONIST

被引：90
作者：
LEMBERGER, L
CRABTREE, RE
机构：
[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202
[3] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202
来源：
SCIENCE | 1979年 / 205卷 / 4411期
关键词：
D O I：
10.1126/science.382359
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percent) and gradually return to control levels several days after drug administration is discontinued. Copyright © 1979 AAAS.
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页码：1151 / 1153
页数：3
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