EXPRESSION OF GAP JUNCTION PROTEIN CONNEXIN-32 AND E-CADHERIN IN HUMAN HEPATOCELLULAR-CARCINOMA

被引：33

作者：

YAMAOKA, K

NOUCHI, T

TAZAWA, J

HIRANUMA, S

MARUMO, F

SATO, C

机构：

[1] TOKYO MED & DENT UNIV,FAC MED,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO MED & DENT UNIV,FAC MED,DIV HLTH SCI,BUNKYO KU,TOKYO 113,JAPAN

[3] HOKUSHIN GEN HOSP,DIV INTERNAL MED,NAGANO,JAPAN

[4] SHOWA GEN HOSP,DIV GASTROENTEROL,TOKYO,JAPAN

[5] TSUCHIURA KYODO GEN HOSP,DIV INTERNAL MED,IBARAKI,OSAKA,JAPAN

[6] TSUCHIURA KYODO GEN HOSP,DIV SURG,IBARAKI,OSAKA,JAPAN

来源：

JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 05期

关键词：

ADHESION MOLECULE; CELL-TO-CELL COMMUNICATION; CIRRHOSIS; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0168-8278(95)80447-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The expression of connexin 32, a major gap junction protein, and E-cadherin, an intercellular adhesion molecule that is supposed to be involved in the regulation of gap junctional intercellular communications, was examined immunohistochemically in seven specimens of human hepatocellular carcinoma and surrounding non-carcinomatous tissues. We found that the number of connexin 32-positive spots per mm(2) was significantly less in hepatocellular carcinoma tissues than in the surrounding non-carcinomatous cirrhotic tissues (4360+/-3390/mm(2) vs 10 030+/-3690/mm(2); p<0.01). The number in the latter was also significantly less than that in normal controls (23 560+/-4170/mm(2)). E-cadherin was expressed in all non-carcinomatous hepatocytes as well as carcinomatous cells, except for one case of Edmondson's grade III hepatocellular carcinoma. These results suggest an impairment of cell-to-cell communications in human hepatocellular carcinomas.

引用

页码：536 / 539

页数：4

共 15 条

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