INVITRO ACTIVITY OF DNA GYRASE INHIBITORS, SINGLY AND IN COMBINATION, AGAINST MYCOBACTERIUM-AVIUM COMPLEX

被引：3

作者：

BABINCHAK, TJ ^{[1
]}

FASS, RJ ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT INTERNAL MED, DIV INFECT DIS, COLUMBUS, OH 43210 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1992年 / 15卷 / 04期

关键词：

D O I：

10.1016/0732-8893(92)90026-P

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in Vitro activities of the DNA gyrase inhibitors ciprofloxacin, coumermycin, and novobiocin against 31 clinical isolates of Mycobacterium avium complex were studied using a microdilution technique. Minimal inhibitory concentrations (MICS) were determined in 4 days using Middlebrook 7H9 broth, and minimal bactericidal concentrations (MBCs) were determined by subculturing to Middlebrook 7H10 agar. MICs were: ciprofloxacin, 0.5- > 16 (mean, 4.1) mu-g/ml; novobiocin, 4- > 128 (mean, 54.7) mu-g/ml; and coumermycin, 2- > 16 (mean, 17.5) mu-g/ml. MBCs were usually more than two dilution steps higher than MICs. Checkerboard studies failed to reveal synergistic or antagonistic inhibitory activity of DNA gyrase-A and DNA gyrase-B inhibitors in vitro.

引用

页码：367 / 370

页数：4

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