STIMULATION OF P21RAS UPON T-CELL ACTIVATION

被引：889

作者：

DOWNWARD, J ^{[1
]}

GRAVES, JD ^{[1
]}

WARNE, PH ^{[1
]}

RAYTER, S ^{[1
]}

CANTRELL, DA ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,LYMPHOCYTE ACTIVAT LAB,LONDON WC2A 3PX,ENGLAND

来源：

NATURE | 1990年 / 346卷 / 6286期

关键词：

D O I：

10.1038/346719a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C. © 1990 Nature Publishing Group.

引用

页码：719 / 723

页数：5

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