STIMULATION OF P21RAS UPON T-CELL ACTIVATION

被引：888
|
作者：
DOWNWARD, J [1 ]
GRAVES, JD [1 ]
WARNE, PH [1 ]
RAYTER, S [1 ]
CANTRELL, DA [1 ]
机构：
[1] IMPERIAL CANC RES FUND,LYMPHOCYTE ACTIVAT LAB,LONDON WC2A 3PX,ENGLAND
来源：
NATURE | 1990年 / 346卷 / 6286期
关键词：
D O I：
10.1038/346719a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C. © 1990 Nature Publishing Group.
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收藏
页码：719 / 723
页数：5
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