CHICKEN OVALBUMIN CONTAINS AN INTERNAL SIGNAL SEQUENCE

被引：197

作者：

LINGAPPA, VR

LINGAPPA, JR

BLOBEL, G

机构：

[1] Laboratory of Cell Biology, Rockefeller University, New York

来源：

NATURE | 1979年 / 281卷 / 5727期

关键词：

D O I：

10.1038/281117a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ovalbumin is shown to contain an internal rather than an amino-terminal signal sequence. This internal signal can be recovered in a tryptic fragment which comprises residues 229-276 of mature ovalbumin and contains a region of striking sequence homology to amino-terminal cleaved signals of two other oviduct secretory proteins. The isolated tryptic fragment is used as a probe to demonstrate that a signal receptor is present in membrane vesicles derived from the rough but not in those derived from the smooth endoplasmic reticulum. © 1979 Nature Publishing Group.

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页码：117 / 121

页数：5

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