MECHANISM OF SPONTANEOUS, CONCENTRATION-DEPENDENT PHOSPHOLIPID TRANSFER BETWEEN BILAYERS

被引：75

作者：

JONES, JD ^{[1
]}

THOMPSON, TE ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908

来源：

BIOCHEMISTRY | 1990年 / 29卷 / 06期

关键词：

D O I：

10.1021/bi00458a034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously demonstrated that spontaneous phospholipid transfer between bilayer vesicles at higher vesicle concentrations is characterized not only by a first-order desorption rate but also by a second-order process dependent on vesicle concentration (Jones & Thompson, 1989b). We have extended our studies to examine the mechanism of this second-order process by investigating transfer as a function of lipid type, temperature, aqueous medium composition, and vesicle size. The results suggest a mechanism of concentration-dependent transfer in which the rate of lipid monomer desorption from vesicle bilayers is enhanced in transient vesicle-vesicle complexes. © 1990, American Chemical Society. All rights reserved.

引用

页码：1593 / 1600

页数：8

共 41 条

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